Molecular Formula | C18H29ClN2O4 |
Molar Mass | 372.89 |
Melting Point | 141-1430C |
Boling Point | 564.1°C at 760 mmHg |
Flash Point | 295°C |
Solubility | Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone and in methylene chloride. |
Vapor Presure | 1.45E-13mmHg at 25°C |
Appearance | neat |
Color | White to Pale Yellow |
Storage Condition | 2-8°C |
In vitro study | Acebutolol inhibits the uptake of NA by the P2 fragment of rat brain with an IC50 of 0.25 mM. Acebutolol inhibits Acebutolol (does not bind to LDL) on J774 macrophages and has a stronger inhibitory effect on intracellular accumulation of cholesteryl esters than Alprenolol and Oxprenolol (binds to LDL). |
In vivo study | Acebutolol(10 mg/kg), administered intravenously alone to rats, resulted in a plasma clearance of 61.9 mL/min/kg, a volume of distribution of 9.6L/kg, and an elimination half-life of 1.8 hours. Acebutolol(50 mg/kg), administered intravenously alone to rats, had a plasma clearance of 46.5 mL/min/kg, a volume of distribution of 9.5L/kg, and an elimination half-life of 2.3 hours. In Sprague-Dawley rats treated with Acebutolol (30 mg/kg), cardiac output decreased by 65% and 31% as measured at 1 and 10 minutes, respectively. Treatment of Sprague-Dawley rats with Acebutolol (30 mg/kg), measured 1 or 10 minutes later, showed a significant decrease in regional blood flow (RBF) in most organs. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | 36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | ES5235000 |
HS Code | 2924296000 |
Toxicity | LD50 orl-rat: 6620 mg/kg OYYAA2 20,883,80 |